Cannabidiol Found to Reduce Seizure Frequency in New Trail

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Cannabidiol (CBD) Found to Reduce Seizure Frequency in Phase III Trial The oral administration of CBD (cannabidiol) reduces seizure frequency in children with intractable epilepsy, according to placebo-controlled, randomized trial data published in The New England Journal of Medicine. In this double-blind, placebo-controlled trial, they randomly assigned 120 children and young adults with the Dravet syndrome and drug-resistant seizures to … Read More

Vanilloid Receptors

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Vanilloid Receptors

CBD directly interacts with various ion channels to confer a therapeutic effect. CBD, for example, binds to TRPV1 receptors, which also function as ion channels. TRPV1 is known to mediate pain perception, inflammation and body temperature. TRPV is the technical abbreviation for “transient receptor potential cation channel subfamily V.” TRPV1 is one of several dozen TRP (pronounced “trip”) receptor variants … Read More

CBD as an allosteric modulator

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allosteric modulator

Allosteric Modulator Australian scientists report that CBD acts as a “positive allosteric modulator” of the GABA-A receptor. In other words, CBD interacts with the GABA-A receptor in a way that enhances the receptor’s binding affinity for its principal endogenous agonist, gamma-Aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. The sedating effects of Valium … Read More

CBD Reuptake Inhibitor – Hitching a Ride with a FABP

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Tourettes Syndrome

CBD Reuptake Inhibitor How does CBD, an exogenous plant compound, get inside a human cell to bind to a nuclear receptor? First it has to pass through the cell membrane by hitching a ride with a fatty acid binding protein (FABP), which chaperones various lipid molecules into the cell’s interior. These intracellular transport molecules also escort tetrahydrocannabinol (THC) and the … Read More

Anxiety, Depression and treating it with Cannabidiol

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Anxiety and depression are two of the most common mental health concerns in the world today. In fact, the chances are fairly good that you, the reader, have dealt with (or will deal with) a clinically-diagnosable level of anxiety of depression at some point during your lifetime—whether it’s lasting or temporary. According to statistics released by the Anxiety and Depression … Read More

Chronic Pain and The Benefits of Cannabidiol

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Chronic Pain

Chronic Pain If you’re at all familiar with cannabis or cannabidiol (CBD), you’re probably well aware of its use in the medical realm as an option for the treatment of pain. The analgesic benefits of CBD via the body’s endocannabinoid system have been well-researched, with numerous clinical trials supporting claims of its effectiveness for pain.  But those who suffer with … Read More

CBD an Antipsychotic?

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CBD an Antipsychotic? Studies have shown CBD may relieve psychotic symptoms associated with schizophrenia, according to research by University of Cologne in Germany. Schizophrenia affects about 1.1 percent of the population, or approximately 2.4 million adults in the United States. CBD continues to surprise researchers with the variety of common health benefits it provides. An increasing number of scientists, physicians … Read More

CBD Is A Possible Treatment for MS

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CBD and MS

Scientists at the Cajal Institute used animal models and cell cultures to find that CBD reversed inflammatory responses and served as durable protection from the effects of multiple sclerosis. Mice with 10 days of CBD treatment had superior motor skills and showed progression in their condition. Using this information, researchers concluded that CBD has the potential ability to reduce various … Read More

CBD and Crohn's Disease

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CBD and Crohn's

CBD and Crohn’s Some scientists say CBD could be an effective treatment for bowel diseases like Crohn’s Disease. THC and CBD interact with the system that controls gut function in the body, something that Crohn’s patients suffer issues with. The component of cannabis’ anti-inflammatory ability brings a lot of relief to those suffering from this condition. I found a first … Read More